
Newest Research

Selected Publications
Daughters RS, Julian L, Knock E, Willerth SM. Editorial: Next generation in vitro models of the human blood - brain/cerebrospinal fluid barrier. Frontiers in Molecular Neuroscience (2024) 17:1371733. Pubmed
Nazir S, Feresten AH, Lin L, Hutter H, Julian LM. Extracellular Matrix of the Nervous System. Handbook of Neural Engineering: A Modern Approach. Elsevier (2023). Link
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Dawoody Nejad L, Julian LM. Stem cell-derived organoid models for SARS-CoV-2 and its molecular interaction with host cells. Mol Biol Rep. (2023). 50(12): 10627-10635 Pubmed
Pietrobon A, Yockell-Lelièvre J, Melong N, Smith LJ, Delaney SP, Azzam N, Xue C, Merwin N, Lian E, Camacho-Magallanes A, Doré C, Musso G, Julian LM, Kristof AS, Tam RY, Berman JN, Shoichet MS, Stanford WL. Tissue-Engineered Disease Modeling of Lymphangioleiomyomatosis Exposes a Therapeutic Vulnerability to HDAC Inhibition. Advanced Science (2023). 10(26): e2302611 Pubmed
Venkateshappa R, Hunter DV, Muralidharan P, Nagalingham RS, Huen G, Faizi S, Luthra S, Lin E, Cheng YM, Hughes J, Khelifi R, Dhunna DP, Johal R, Sergeev V, Shafaattalab S, Julian LM, Poburko D, Laksman Z, Tibbits GF, Claydon TW. Targeted activation of human ether-à-go-go-related gene channels rescues electrical instability induced by the R56Q+/- long QT syndrome variant. Cardiovascular Res. (2023). 119(15): 2522-2535 Pubmed
George E. Allen, Aaron S. Dhanda, and Lisa M. Julian. Emerging Methods in Modeling Brain Development and Disease with Human Pluripotent Stem Cells. Methods in Molecular Biology (2022). 2515:319-342. Pubmed
Erin Knock and Lisa M Julian. Building on a solid foundation: adding relevance and reproducibility to neurological modeling using human pluripotent stem cells. Frontiers in Cellular Neuroscience (2021). 15:767457. Pubmed
Julian LM and Stanford WL. Organelle cooperation in stem cell fate: lysosomes as emerging regulators of cell identity. Frontiers in Cell and Developmental Biology, section Stem Cell Research; Special issue: The Role of Metabolism in Stem Cell Fates. (2020). 8:591. Pubmed
Sean P. Delaney, Lisa M. Julian, Adam Pietrobon, Julien Yockell-Lelièvre, Carole Dore, Ting T Wang, Valerie C Doyon, Angela Raymond, David A. Patten, Mary-Ellen Harper, Hongyu Sun, and William L. Stanford. Human pluripotent stem cell modeling of tuberous sclerosis complex reveals lineage-specific therapeutic vulnerabilities. (2020).
bioRxiv 683359; doi: https://doi.org/10.1101/683359
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Huang T, Gonzalez YR, Qu D, Huang E, Safarpour F, Wang E, Joselin A, Im DS, Callaghan SM, Boonying W, Julian L, Dunwoodie SL, Slack RS, and Park DS. The pro-death role of Cited2 in Stroke is regulated by E2F1/4 transcription factors. J Biol Chem. (2019). 294(21): 8617-8629. Pubmed
Tam RY, Yockell-Lelièvre J, Smith LJ, Julian LM, Baker AEG, Choey C, Hasim MS, Dimitroulakos J, Stanford WL, and Shoichet MS. Rationally-Designed 3D Hydrogels Model Invasive Lung Diseases Enabling High Content Drug Screening. Advanced Materials (2018). Dec 27:e1806214. PMID: 30589121. Pubmed
Chen Z, Pietrobon A, Julian LM, and Stanford WL. Somatic cell epigenetic reprogramming: molecular mechanisms and therapeutic potential. In D. Palacios (Ed), Epigenetics and Reprogramming (2018). Elsevier (Academic Press). Link
Lavictoire SJ, Gont A, Julian LM, Stanford WL, Vlasschaert C, Gray D, Jomaa D, Lorimer IAJ. Engineering PTEN-L for cell-mediated delivery. Molecular Therapy – Methods and Clinical Development (2017). 9:12-22. Pubmed
Lisa M Julian, and William L. Stanford. Reprogramming patient-derived tumour cells
generates model cell lines for tuberous sclerosis-associated lymphangioleiomyomatosis. Oncoscience (2017). 4(11-12):170-172. Pubmed
Julian LM, Delaney SP, Wang Y, Goldberg AA, Doré C, Yockell-Lelièvre J, Tam RY, Giannikou K, McMurray F, Shoichet MS, Harper ME, Henske EP, Kwiatkowski DJ, Darling TN, Moss J, Kristof AS, Stanford WL. Human Pluripotent Stem Cell-Derived TSC2-Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis. Cancer Research (2017). 77(20):5491-5502. Pubmed
Julian LM, McDonald AC, and Stanford WL. Direct reprogramming with SOX factors: masters of cell fate. Current Opinion in Genetics & Development (2017). 46:24-36. Pubmed
Julian LM, Carpenedo RL, Rothberg JL, and Stanford WL. Formula G1: Cell cycle in the driver’s seat of stem cell fate determination. Bioessays (2016). 38(4):325-332. *Journal cover. Pubmed
Carpenedo RL, Julian LM, and Stanford WL. Human pluripotent stem cells. Methods (2016). 101:1-3. Pubmed
Lisa M Julian and Alexandre Blais. Transcriptional control of stem cell fate by E2Fs and pocket proteins. Frontiers in Genetics (2015). 6:161. Pubmed
Lisa M Julian, Yubing Liu, Catherine A Pakenham, Delphie Dugal-Tessier, Vladimir Ruzhynsky, Sooin Bae, Shih-Yin Tsai, Gustavo Leone, Ruth S Slack, and Alexandre Blais. Tissue-specific Targeting of Cell Fate Regulatory Genes by E2f Factors. Cell Death & Differentiation (2016). 23(4):565-575. Pubmed
Sean P Delaney, Lisa M Julian, and William L Stanford. The neural crest lineage as a driver of disease heterogeneity in Tuberous Sclerosis Complex and Lymphangioleiomyomatosis. Frontiers in Cell and Developmental Biology (2014). 2:69. Pubmed
Julian LM, Vandenbosch R, Pakenham CA, Andrusiak MG, Nguyen AP, McClellan KA, Svoboda DS, Lagace DC, Park DS, Leone G, Blais A, and Slack RS. Opposing regulation of Sox2 by cell cycle effectors E2f3a and E2f3b in neural stem cells. Cell Stem Cell (2013). 12(4):440-452. Pubmed
Ghanem N, Andrusiak MG, Svoboda DS, Allafi SM, Julian LM, McClellan KA, De Reptigny Y, Kothary R, Ekker M, Blais A, Park DS, and Slack RS. The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlxi/Dlx2 bigene cluster. Journal of Neuroscience (2012). 32(24):8219-8230. Pubmed
Andrusiak MG, McClellan KA, Dugal-Tessier D, Julian LM, Rodrigues SP, Park DS, and Slack RS. Rb/E2F regulates expression of neogenin during neuronal migration. Molecular and Cellular Biology (2010). 31(2):238-247. Pubmed
McClellan KA, Vanderluit JL, Julian LM, Andrusiak MG, Dugal-Tessier D, Park DS, and Slack RS. The p107/E2F pathway regulates fibroblast growth factor receptor 2 responsiveness in neural precursor cells. Molecular and Cellular Biology (2009). 29(17):4701-4713. Pubmed
Seifried LA, Talluri S, Cecchini M, Julian LM, Mymryk JS, and Dick FA. pRB-E2F1 complexes are resistant to adenovirus E1A-mediated disruption. Journal of Virology (2008). 82(9):4511-4520. Pubmed
LM Julian, O Palander, LA Seifried, JEG Foster, and FA Dick. Characterization of an E2F1-specific binding domain in pRB and its implications for apoptotic regulation. Oncogene (2008). 27(11):1572-1579. Pubmed
Isaac CE, Francis SM, Martens AL, Julian LM, Seifried LA, Erdmann N, Binne UK, Harrington L, Sicinski P, Berube NG, Dyson NJ, and Dick FA. The retinoblastoma protein regulates pericentric heterochromatin. Molecular and Cellular Biology (2006). 26(9):3659-3671. Pubmed